Macular Holes and Macular Pucker: The Role of Vitreoschsis as Imaged By Optical Coherence Tomography/Scanning Laser Ophthalmoscopy

Entities Mentioned

• Keck School of Medicine
• OPKO Health
• OTI Ophthalmic Technologies Inc.
• Harvard University
• Richard B. Rosen
• New York Eye and Ear Infirmary

1. Purpose
   The pathogenesis of macular pucker and macular holes is poorly understood. Anomalous posterior vitreous detachment (PVD) and vitreoschisis have been proposed as possible mechanisms. This study used clinical imaging to seek vitreoschisis and study the topographic features of macular pucker and macular holes.
   
   
   Methods
   Combined optical coherence tomography and scanning laser ophthalmoscopy (OCT/SLO) was performed in 45 eyes with macular hole and 44 eyes with macular pucker. Longitudinal imaging was used to identify vitreoschisis and measure retinal thickness. The topographic features of eyes with macular hole with eccentric macular contraction were compared ... (Read Full Article)
   
   

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