In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography.

Entities Mentioned

• Joseph A. Izatt
• Duke University
• University of Texas at Austin
• University of Arizona
• Jennifer K. Barton
• Ashley J. Welch

1. We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use for in vivo imaging of blood flow in an animal model. Our technique, color Doppler optical coherence tomography (CDOCT), performs spatially localized optical Doppler velocimetry by use of scanning low-coherence interferometry. CDOCT is an extension of optical coherence tomography (OCT), employing coherent signal-acquisition electronics and joint time-frequency analysis algorithms to perform flow imaging simultaneous with conventional OCT imaging. Cross-sectional maps of blood flow velocity with
   PMID: 18188263 [PubMed - in process] (Read Full Article)
   
   

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