1. In-Vitro Characterization of Ablation Lesions Using Oct

    Circulation (Nov 10 2008) Cardiology Explore Article

    Radiofrequency ablation (RFA) is a clinical procedure that destroys tissue to cure cardiac arrhythmias. Presently, there is no direct method to monitor RFA lesion formation in real-time. Real time direct monitoring of the tissue could guide ablation and prevent complications such as tissue disruption that leads to perforation. Optical coherence tomography (OCT) provides real-time subsurface imaging with high spatial resolution in three dimensions. We hypothesized that OCT can distinguish necrotic ... (Read Full Article)

    Comment on Article Mentions:   Andrew M. Rollins   Case Western Reserve University   Wang Yuhl Oh

  2. Bimodal biophotonic imaging of the structure-function relationship in cardiac tissue

    SPIE Digital Library (Sep 10 2008) Cardiology Explore Article

    William J. Hucker, Crystal M. Ripplinger, Christine P. Fleming et al. The development of systems physiology is hampered by the limited ability to relate tissue structure and function in intact organs in vivo or in vitro. Here, we show the application of a bimodal biophotonic imaging approach that employs optical coherence tomography and fluorescent imaging to investig ... [J. Biomed. Opt. 13, 054012 (2008)] published Wed Sep 10, 2008. (Read Full Article)

    Comment on Article Mentions:   Case Western Reserve University   Andrew M. Rollins   Washington University in St. Louis

  3. Quantification of cardiac fiber orientation using optical coherence tomography

    SPIE Digital Library (Jun 20 2008) Cardiology Explore Article

    Christine P. Fleming, Crystal M. Ripplinger, Bryan Webb et al. Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart ... [J. Biomed. Opt. 13, 030505 (2008)] published Fri Jun 20, 2008. (Read Full Article)

    Comment on Article Mentions:   Andrew M. Rollins   Case Western Reserve University

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