Articles from Zhongping Chen

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Application: Art, Bronchoscopy, Cardiology, Dentistry, Dermatology, Developmental Biology, Endoscopy, Glucose, Gynecology, Microscopy, NDE/NDT, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Urology
Miscellaneous: Acquisition, Clinical Trials, Funding, Jobs & Studentships, Partnership, Patents, Textbooks
Technology: Broadband Sources, Probes, Propagation, Tunable Sources

  1. Effect of Erythrocyte Aggregation on Hematocrit Measurement Using Spectral-Domain Optical Coherence Tomography

    Explore Article IEEE Xplore (Dec 30 2008)

    Optical coherence tomography (OCT) has the potential to be a noninvasive method for hematocrit (HCT) measurement. This study shows the effect of erythrocyte aggregation at the level seen in healthy humans and pathological states on HCT measurement based on monitoring the slope changes in OCT depth reflectivity profile using spectral-domain optical coherence tomography (SDOCT). Our measurement indicates that the HCT estimated by SDOCT depends on the erythrocyte aggregation state and ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  2. Imaging the Human Tympanic Membrane Using Optical Coherence Tomography In Vivo.

    Explore Article Otology & Neurotology (Nov 24 2008) Otolaryngology

    Objective: Optical coherence tomography (OCT) is a diagnostic imaging modality that combines low coherence light with interferometry to produce high-resolution cross-sectional images of living tissues. Using this technology, we have imaged in vivo the human tympanic membrane (TM) in the office clinic setting and characterized TM microstructure in normal and pathologic conditions. Study Design: Prospective clinical trial. Materials and Methods: The normal and diseased TMs in 10 adult subjects were ... (Read Full Article)

    Comment on Article Mentions:   Imalux   Imalux Niris   Zhongping Chen

  3. In Vivo Optical Coherence Tomography of the Human Oral Cavity and Oropharynx

    Explore Article archotol.ama-assn.org (Nov 24 2008) Otolaryngology

    Optical coherence tomography (OCT) is an evolving imaging modality that combines interferometry with low-coherence light to produce high-resolution tissue imaging. Cross-sectional in vivo images were obtained using an OCT device consisting of a Michelson interferometer, 1.3-µm broadband light source, and a handheld fiberoptic imaging probe. Image pixel resolution approached 10 µm. The mucosa of the oral cavity and oropharynx were examined in 41 patients during operative endoscopy. Optical coherence tomographic ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine   Shuguang Guo

  4. Optical Coherence Tomography and Optical Doppler Tomography (Book Chapter)

    Explore Article SpringerLink Home (Sep 21 2008) Textbooks

    Book Chapter in Encyclopedia of Microfluidics and Nanofluidics. No Abstract Provided (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  5. Topographical variations in the polarization sensitivity of articular cartilage as determined by polarization-sensitive optical coherence tomography and polarized light microscopy

    Explore Article SPIE Digital Library (Sep 5 2008)

    Tuqiang Xie, Yang Xia, Shuguang Guo et al. To understand the influence of topographical variations in collagen fibril orientation of articular cartilage on optical phase images of polarization-sensitive optical coherence tomography (PS-OCT), we use polarized light microscopy (PLM) to quantify the orientation and phase retardation of the coll ... [J. Biomed. Opt. 13, 054034 (2008)] published Fri Sep 5, 2008. (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine   Shuguang Guo

  6. Imaging pulsatile retinal blood flow in human eye

    Explore Article SPIE Digital Library (Aug 25 2008) Ophthalmology

    Bin Rao, Lingfeng Yu, Huihua Kenny Chiang et al. A functional Fourier domain optical coherence tomography instrument offering spectral Doppler imaging of in vivo pulsatile human retinal blood flow was constructed. An improved phase-resolved algorithm was developed to correct bulk motion artifacts. Spectral Doppler imaging provides complementary te ... [J. Biomed. Opt. 13, 040505 (2008)] published Mon Aug 25, 2008. (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  7. Optical Coherence Tomography–Enhanced Microlaryngoscopy: Preliminary Report of a Noncontact Optical Coherence Tomography System Integrated With a Surgical Microscope

    Explore Article annals.com (Aug 15 2008) Microscopy , Otolaryngology

    Objectives: Optical coherence tomography (OCT) is a new imaging modality that uses near-infrared light to produce cross-sectional images of tissue with a resolution approaching that of light microscopy. We have previously reported use of OCT imaging of the vocal folds (VFs) during direct laryngoscopy with a probe held in contact or near-contact with the VFs. This aim of this study was to develop and evaluate a novel OCT system integrated ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine   Shuguang Guo

  8. Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor

    Explore Article SPIE Digital Library (Jul 1 2008) Bronchoscopy , Endoscopy , Tunable Sources

    Jianping Su, Jun Zhang, Lingfeng Yu et al. A fast-scan-rate swept laser for optical coherence tomography (OCT) is suitable to record and analyze a 3-D image volume. However, the whole OCT system speed is limited by data streaming, processing, and storage. In this case, postprocessing is a common technique. Endoscopic clinical applications pr ... [J. Biomed. Opt. 13, 030506 (2008)] published Tue Jul 1, 2008. (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  9. Optical Coherence Tomography of the Newborn Airway

    Explore Article annals.com (Jun 21 2008) Bronchoscopy , Otolaryngology

    Objectives: Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine   Shuguang Guo

  10. High-speed and wide bandwidth Fourier domain mode-locked wavelength swept laser with multiple SOAs.

    Explore Article NCBI HomePage (Jun 11 2008)

    Related Articles High-speed and wide bandwidth Fourier domain mode-locked wavelength swept laser with multiple SOAs. Opt Express. 2008 Feb 18;16(4):2547-54 Authors: Jeon MY, Zhang J, Wang Q, Chen Z We report on the development of a high-speed, wide bandwidth Fourier domain mode-locked (FDML) wavelength swept laser of around 1300 nm using two gain media for high-resolution and high-speed Fourier domain optical coherence tomography. The wavelength swept laser is capable of ... (Read Full Article)

    Comment on Article Mentions:   University of California at Irvine   Zhongping Chen

  11. Optical Coherence Tomography of the Cochlea in the Porcine Model.

    Explore Article The Laryngoscope (May 15 2008) Otolaryngology

    Abstract: Objectives/Hypothesis: To demonstrate the feasibility of optical coherence tomography in microstructural imaging of the porcine cochlea. Study Design: Ex vivo, porcine model. Methods: Optical coherence tomographic images of the porcine cochlea were obtained by thinning the bone from the basal turn of the cochlea leaving the endosteum intact. The images were compared with the corresponding histological sections. Results: In the areas of thinned bone, images were obtained of the ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  12. Optical clearing of flowing blood using dextrans with spectral domain optical coherence tomography

    Explore Article SPIE Digital Library (Apr 29 2008) Cardiology

    Xiangqun Xu, Lingfeng Yu, and Zhongping Chen Spectral domain optical coherence tomography (SDOCT) images have been used to investigate the mechanism of optical clearing in flowing blood using dextrans. The depth reflectivity profiles from SDOCT indicate that dextrans become increasingly more effective in reducing scattering in flowing blood, e ... [J. Biomed. Opt. 13, 021107 (2008)] published Tue Apr 29, 2008. (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  13. High speed spectral domain functional optical coherence tomography and optical doppler tomography for in vivo blood flow dynamics and tissue structure

    Explore Article PatFT » Page 1 of 1 (Apr 15 2008) Patents

    A system for tomographic imaging includes a source of at least partially coherent radiation, a frequency-swept laser source and an interferometer. The radiation in the interferometer is phase modulated at a modulation frequency for elimination of DC and autocorrelation noises as well as the mirror image. The interference fringes of the radiation backscattered from the sample into the interferometer are detected to obtain a spectral signal. The spectral signal of ... (Read Full Article)

    Comment on Article Mentions:   Micron Optics   John S. Nelson   Zhongping Chen

  14. Characterization of Fourier domain modelocked wavelength swept laser for optical coherence tomography imaging

    Explore Article opticsinfobase.org (Mar 6 2008) Tunable Sources

    Min Yong Jeon, Jun Zhang, Zhongping Chen. We present characteristics of a wavelength swept laser with a scanning fiber Fabry-Perot filter at 1300 nm. We investigate the dependence of the scanning frequencies in the swept laser. In conventional wavelength swept lasers, the relative intensity of the laser output decreases significantly as ... [Opt. Express 16, 3727-3737 (2008)] (Read Full Article)

    Comment on Article Mentions:   Jun Zhang   Zhongping Chen   University of California at Irvine

  15. Imaging treated brain aneurysms in vivo using optical coherence tomography

    Explore Article SPIE Digital Library (Feb 18 2008) Cardiology

    Jianping Su, Marlon S. Mathews, Chiedozie I. Nwagwu et al. Angiography is currently used to assess post-treatment human brain aneurysm healing, which can reveal vessel shape only. Optical coherence tomography (OCT) can reveal the vessel wall structure with high resolution, which has the advantage to assess vessel healing progress. An OCT endovascular cathet ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 684732 (2008)] published Mon Feb 18, 2008. (Read Full Article)

    Comment on Article

  16. In vitro 3D articular cartilage imaging using endoscopic spectral domain optical coherence tomography (sd-oct) with a GRIN (gradient index) lens rod based probe

    Explore Article SPIE Digital Library (Feb 18 2008) Endoscopy

    Tuqiang Xie, Yehchan Ahn, Zhongping Chen et al. In this paper, a GRIN lens rod based dynamic focusing spectral domain optical coherence tomography (OCT) system with 2D scanners is presented and is used to investigate a fresh bovine joint in vitro by 3D OCT with lateral and axial resolutions of 10 [mu]m at the speed of 8 frames/s. The experimental ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 684730 (2008)] ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen

  17. In vivo 3-D imaging of gastrointestinal tract by use of an endoscopic swept source optical coherence tomography with a microelectromechanical endoscopic rotational probe

    Explore Article SPIE Digital Library (Feb 18 2008) Endoscopy , Probes

    Jun Zhang, Jianping Su, Kenneth Chang et al. In vivo three dimensional endoscopic imaging of rabbit and human gastrointestinal tracts was demonstrated based on an endoscopic swept source optical coherence tomography (SSOCT) system. The endoscopic SSOCT system is composed of a high speed SSOCT, a fast scanning rotational microelectromechanical ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 68472Y (2008)] published Mon Feb 18, 2008. (Read Full Article)

    Comment on Article

  18. High speed broadband Fourier domain mode locked swept source with multiple SOAs

    Explore Article SPIE Digital Library (Feb 18 2008) Tunable Sources

    Jun Zhang, Min Yong Jeon, and Zhongping Chen A high-speed, broadband Fourier domain mode-locked (FDML) wavelength swept source at center wavelength of 1300 nm for high-resolution and high-speed Fourier domain optical coherence tomography was demonstrated. With two semiconductor optical amplifiers as gain media, the laser is capable of FWHM tun ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 684712 (2008)] published Mon Feb 18, 2008. (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  19. Analysis of surface-tension-driven blood flow using spectral domain optical coherence tomography

    Explore Article SPIE Digital Library (Feb 13 2008)

    Yeh-Chan Ahn, Salvatore Cito, Ioanis Katakis et al. A passive pumping for lab-on-a-chip using surface tension only is the most effective method because the effect of surface tension on a flow is significant in microscale. The movement of the triple point at a meniscus is driven by surface tension, resisted by viscous stress, and balanced by inertial ... [Proc. SPIE Int. Soc. Opt. Eng. 6886, 68860S (2008)] published Wed Feb ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen

  20. High-speed and wide bandwidth Fourier domain mode-locked wavelength swept laser with multiple SOAs

    Explore Article opticsinfobase.org (Feb 12 2008)

    Min Yong Jeon, Jun Zhang, Qiang Wang, Zhongping Chen We report on the development of a high-speed, wide bandwidth Fourier domain mode-locked (FDML) wavelength swept laser of around 1300 nm using two gain media for high-resolution and high-speed Fourier domain optical coherence tomography. The wavelength swept laser is capable of FWHM scanning range ... [Opt. Express 16, 2547-2554 (2008)] (Read Full Article)

    Comment on Article Mentions:   Jun Zhang   Zhongping Chen   University of California at Irvine

  21. Imaging of the Pediatric Airway Using Optical Coherence Tomography.

    Explore Article The Laryngoscope (Dec 4 2007) Bronchoscopy , Endoscopy , Otolaryngology

    Laryngoscope. 117(12):2206-2212, December 2007. Ridgway, James Matthew MD; Ahuja, Gurpreet MD; Guo, Shuguang PhD; Su, Jianping BS; Mahmood, Usama BS; Chen, Zhongping PhD; Wong, Brian MD, PhD Abstract: Objectives: Optical coherence tomography (OCT) is an imaging modality that uses a broadband light source to produce high-resolution cross-sectional images in living tissue (8-20 [mu]m). A prospective study of normal, benign, and pathologic tissues in the pediatric airway was conducted to assess ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine   Shuguang Guo

  22. In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror

    Explore Article opticsinfobase.org (Nov 7 2007) Endoscopy

    Woonggyu Jung, Daniel T. McCormick, Yeh-Chan Ahn, Ali Sepehr, Matt Brenner, Brian Wong, Norman C. Tien, Zhongping Chen A biopsy is a well-known medical test used to evaluate tissue abnormality. Biopsy specimens are invasively taken from part of a lesion and visualized by microscope after chemical treatment. However, diagnosis by means of biopsy is not only variable due to depth and location of specimen but may also ... [Opt. Lett. ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  23. In vivo optical coherence tomography--based scoring of oral mucositis in human subjects: a pilot study

    Explore Article SPIE Digital Library (Sep 21 2007) Dentistry

    Hilari Kawakami-Wong, Shuguang Gu, Marie J. Hammer-Wilson et al. A preliminary study to assess noninvasive optical coherence tomography (OCT) for early detection and evaluation of chemotherapy-induced oral mucositis in five patients. In five patients receiving neoadjuvant chemotherapy for primary breast cancer, oral mucositis was assessed clinically, and imaged u ... [J. Biomed. Opt. 12, 051702 (2007)] published Fri Sep 21, 2007. (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  24. Method and apparatus for performing second harmonic optical coherence tomography

    Explore Article PatFT » Page 1 of 1 (Aug 14 2007) Patents

    The invention is an apparatus and method for second harmonic optical coherence tomography of a sample comprising a laser coupled to an interferometer which has a reference arm and in a sample arm. A nonlinear crystal in the reference arm generates a second harmonic reference signal. The sample typically backscatters some second harmonic light into the sample arm. A broadband beam splitter optically coupled to the reference arm and sample ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  25. High resolution optical coherence tomography with an improved depth range using an axicon lens

    Explore Article PatFT » Page 1 of 1 (Jul 4 2006) Patents

    In optical coherence tomography (OCT), Axial and lateral resolutions are determined by the source coherence length and numerical aperture of the sampling lens, respectively. While axial resolution can be improved using a broadband light source, there is a trade-off between lateral resolution and focusing depth when conventional optical elements are used. The incorporation of an axicon lens into the sample arm of the interferometer overcomes this limitation. Using an axicon ... (Read Full Article)

    Comment on Article Mentions:   Cambridge Technology   John S. Nelson   Zhongping Chen

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