1. In Vivo Optical Coherence Tomography of the Human Oral Cavity and Oropharynx

    archotol.ama-assn.org (Nov 24 2008) Explore Article

    Optical coherence tomography (OCT) is an evolving imaging modality that combines interferometry with low-coherence light to produce high-resolution tissue imaging. Cross-sectional in vivo images were obtained using an OCT device consisting of a Michelson interferometer, 1.3-µm broadband light source, and a handheld fiberoptic imaging probe. Image pixel resolution approached 10 µm. The mucosa of the oral cavity and oropharynx were examined in 41 patients during operative endoscopy. Optical coherence tomographic ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine   Shuguang Guo

  2. Optical Coherence Tomography–Enhanced Microlaryngoscopy: Preliminary Report of a Noncontact Optical Coherence Tomography System Integrated With a Surgical Microscope

    annals.com (Aug 15 2008) Endoscopy , Microscopy Explore Article

    Objectives: Optical coherence tomography (OCT) is a new imaging modality that uses near-infrared light to produce cross-sectional images of tissue with a resolution approaching that of light microscopy. We have previously reported use of OCT imaging of the vocal folds (VFs) during direct laryngoscopy with a probe held in contact or near-contact with the VFs. This aim of this study was to develop and evaluate a novel OCT system integrated ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine   Shuguang Guo

  3. Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor

    SPIE Digital Library (Jul 1 2008) Bronchoscopy , Endoscopy Explore Article

    Jianping Su, Jun Zhang, Lingfeng Yu et al. A fast-scan-rate swept laser for optical coherence tomography (OCT) is suitable to record and analyze a 3-D image volume. However, the whole OCT system speed is limited by data streaming, processing, and storage. In this case, postprocessing is a common technique. Endoscopic clinical applications pr ... [J. Biomed. Opt. 13, 030506 (2008)] published Tue Jul 1, 2008. (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  4. In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit model

    SPIE Digital Library (Jun 23 2008) Bronchoscopy , Endoscopy Explore Article

    Matthew Brenner, Kelly Kreuter, Johnny Ju et al. Smoke inhalation injury causes acute airway injury that may result in airway compromise with significant morbidity and mortality. We investigate the ability of high resolution endobronchial optical coherence tomography (OCT) to obtain real-time images for quantitatively assessing regional difference ... [J. Biomed. Opt. 13, 034001 (2008)] published Mon Jun 23, 2008. (Read Full Article)

    Comment on Article Mentions:   University of California at Irvine   Shuguang Guo

  5. Optical Coherence Tomography of the Newborn Airway

    annals.com (Jun 21 2008) Bronchoscopy Explore Article

    Objectives: Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine   Shuguang Guo

  6. Optical coherence tomography of the larynx in the awake patient

    ScienceDirect (Mar 25 2008) Endoscopy Explore Article

    Objective To demonstrate the feasibility of performing optical coherence tomography of the human larynx on the awake patient with a novel flexible fiberoptic delivery system. Study Design Prospective clinical trial. Subjects and Methods Imaging was performed in 17 awake patients. A flexible optical coherence tomography probe was inserted through the nose and placed in near or gentle contact with laryngeal tissues under direct endoscopic visualization. Results Images were successfully obtained ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   Shuguang Guo   University of California at Irvine

  7. Imaging treated brain aneurysms in vivo using optical coherence tomography

    SPIE Digital Library (Feb 18 2008) Cardiology Explore Article

    Jianping Su, Marlon S. Mathews, Chiedozie I. Nwagwu et al. Angiography is currently used to assess post-treatment human brain aneurysm healing, which can reveal vessel shape only. Optical coherence tomography (OCT) can reveal the vessel wall structure with high resolution, which has the advantage to assess vessel healing progress. An OCT endovascular cathet ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 684732 (2008)] published Mon Feb 18, 2008. (Read Full Article)

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  8. In vivo 3-D imaging of gastrointestinal tract by use of an endoscopic swept source optical coherence tomography with a microelectromechanical endoscopic rotational probe

    SPIE Digital Library (Feb 18 2008) Endoscopy Explore Article

    Jun Zhang, Jianping Su, Kenneth Chang et al. In vivo three dimensional endoscopic imaging of rabbit and human gastrointestinal tracts was demonstrated based on an endoscopic swept source optical coherence tomography (SSOCT) system. The endoscopic SSOCT system is composed of a high speed SSOCT, a fast scanning rotational microelectromechanical ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 68472Y (2008)] published Mon Feb 18, 2008. (Read Full Article)

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  9. Imaging of the Pediatric Airway Using Optical Coherence Tomography.

    The Laryngoscope (Dec 4 2007) Bronchoscopy Explore Article

    Laryngoscope. 117(12):2206-2212, December 2007. Ridgway, James Matthew MD; Ahuja, Gurpreet MD; Guo, Shuguang PhD; Su, Jianping BS; Mahmood, Usama BS; Chen, Zhongping PhD; Wong, Brian MD, PhD Abstract: Objectives: Optical coherence tomography (OCT) is an imaging modality that uses a broadband light source to produce high-resolution cross-sectional images in living tissue (8-20 [mu]m). A prospective study of normal, benign, and pathologic tissues in the pediatric airway was conducted to assess ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine   Shuguang Guo

  10. Detection of acute smoke-induced airway injury in a New Zealand white rabbit model using optical coherence tomography

    SPIE Digital Library (Oct 29 2007) Bronchoscopy Explore Article

    Matthew Brenner, Kelly Kreuter, David Mukai et al. Optical coherence tomography (OCT) is a micron scale high-resolution optical technology that can provide real-time in vivo images noninvasively. The ability to detect airway mucosal and submucosal injury rapidly will be valuable for a range of pulmonary applications including assessment of acute inh ... [J. Biomed. Opt. 12, 051701 (2007)] published Mon Oct 29, 2007. (Read Full Article)

    Comment on Article Mentions:   Shuguang Guo   University of California at Irvine   Matthew Brenner

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