1. Effect of Erythrocyte Aggregation on Hematocrit Measurement Using Spectral-Domain Optical Coherence Tomography

    Explore Article IEEE Xplore (Dec 30 2008)

    Optical coherence tomography (OCT) has the potential to be a noninvasive method for hematocrit (HCT) measurement. This study shows the effect of erythrocyte aggregation at the level seen in healthy humans and pathological states on HCT measurement based on monitoring the slope changes in OCT depth reflectivity profile using spectral-domain optical coherence tomography (SDOCT). Our measurement indicates that the HCT estimated by SDOCT depends on the erythrocyte aggregation state and ... (Read Full Article)

    Comment on Article Mentions:   Zhongping Chen   University of California at Irvine

  2. Combined Effect of Ultrasound-SLS on Skin Optical Clearing

    Explore Article IEEE Xplore (Dec 16 2008) Dermatology

    Our previous studies demonstrated the ultrasound-induced skin optical clearing enhancement with topical application of optical clearing agents on in vitro porcine skin and in vivo human skin. The objective of this study was to develop more effective methods by simultaneously using two kinds of skin permeation enhancers. The effect of ultrasound (SP) in combination with a chemical enhancer, sodium lauryl sulfate (SLS), on skin optical clearing was investigated. Light transmittance ... (Read Full Article)

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  3. Sonophoretic Delivery for Contrast and Depth Improvement in Skin Optical Coherence Tomography

    Explore Article IEEE Xplore (Feb 21 2008) Dermatology

    Our previous studies demonstrated the feasibility of using a sonophoretic delivery method to enhance skin light transmittance with topical application of optical clearing agents using spectroscopy. In this study, we examined the effect of ultrasound [surgeon-performed (SP)] on optical coherence tomography (OCT) imaging depth and contrast of in vitro and in vivo skin. Sixty percent glycerol (G) and SP with a frequency of 1 MHz and a power of 0.75 ... (Read Full Article)

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