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Speckle variance detection of microvasculature using swept-source optical coherence tomography.
NCBI HomePage (Jul 3 2008)
Cardiology
Speckle variance detection of microvasculature using swept-source optical coherence tomography. Opt Lett. 2008 Jul 1;33(13):1530-2 Authors: Mariampillai A, Standish BA, Moriyama EH, Khurana M, Munce NR, Leung MK, Jiang J, Cable A, Wilson BC, Vitkin IA, Yang VX We report on imaging of microcirculation by calculating the speckle variance of optical coherence tomography (OCT) structural images acquired using a Fourier domain mode-locked swept-wavelength laser. The algorithm calculates interframe speckle variance ...
Reports from Harvard University, Cardiology Division highlight recent research in life sciences
newsrx.com (Jun 30 2008)
Cardiology
Current study results from the report, 'Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography study,' have been published. According to recent research from the United States, "Statin therapy induces plaque regression and may stabilize atheromatous plaques. Optical coherence tomography (OCT) is a high-resolution in-vivo imaging modality that allows characterization of atherosclerotic plaques." "We aimed to demonstrate the potential utility of OCT in evaluating coronary plaques ...
Data on thrombosis described by researchers at Medical College
newsrx.com (Jun 30 2008)
Cardiology
According to a study from Harbin, People's Republic of China, "Plaque rupture with subsequent thrombosis is recognised as the underlying pathophysiology of most acute coronary syndromes. Thus, direct thrombus visualisation in vivo may be beneficial for both diagnosis and guidance of therapy." "We sought to test the feasibility of imaging acute thrombosis in vivo using optical coherence tomography (OCT) in an experimental thrombosis animal model. Nine male New Zealand White ...
Early Coverage and Vessel Wall Response of the Zotarolimus Drug-Eluting Stent Implanted in AMI Assessed by Optical Coherence Tomography (OCTAMI)
Home - ClinicalTrials.gov (Jun 26 2008)
Cardiology
The objective of this study is to evaluate the completeness of struts coverage and vessel wall response (strut malapposition, neointima disomogeneities in texture) to the ENDEAVOR drug-eluting stent vs the DRIVER stent (bare metal stent of identical metallic platform) implanted for the treatment of the culprit lesion in ST-elevation acute myocardial infarction (STEMI). To investigate the completeness of the coverage as well as the number of uncovered stent struts per ...
Speckle variance detection of microvasculature using swept-source optical coherence tomography
opticsinfobase.org (Jun 26 2008)
Cardiology
Adrian Mariampillai, Beau A. Standish, Eduardo H. Moriyama, Mamta Khurana, Nigel R. Munce, Michael K. Leung, James Jiang, Alex Cable, Brian C. Wilson, I. Alex Vitkin, Victor X. Yang. We report on imaging of microcirculation by calculating the speckle variance of optical coherence tomography (OCT) structural images acquired using a Fourier domain mode-locked swept-wavelength laser. The algorithm calculates interframe speckle variance in two-dimensional and three-dimensional OCT ... [Opt. Lett. 33, ...
In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography
Oxford Journals (Jun 26 2008)
Cardiology
Aims: Positive coronary arterial remodelling has been shown to be associated with unstable coronary syndromes and ex vivo histological characteristics of plaque vulnerability such as a large lipid core and high macrophage content. The aim of this study is to evaluate the in vivo association between coronary artery remodelling and underlying plaque characteristics identified by optical coherence tomography (OCT). OCT is a unique imaging modality capable of characterizing these important ...
In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography.
NCBI HomePage (Jun 26 2008)
Cardiology
In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography. Eur Heart J. 2008 Jun 24; Authors: Raffel OC, Merchant FM, Tearney GJ, Chia S, Dejoseph Gauthier D, Pomerantsev E, Mizuno K, Bouma BE, Jang IK Aims Positive coronary arterial remodelling has been shown to be associated with unstable coronary syndromes and ex vivo histological characteristics of plaque vulnerability such as a ...
Coherence Tomography Following Paclitaxel Eluting Stent Implantation in Multivessel Coronary Artery Disease (OCTAXUS)
Home - ClinicalTrials.gov (Jun 24 2008)
Cardiology
A prospective Optical Coherence Tomography (OCT) study on the completeness of strut coverage and vessel wall response, at different time points (3-6-9 Months), following TAXUS Liberte stent implantation (staged procedures) in patients with multi vessel native coronary artery lesions. Major concerns were addressed to the delayed healing process of drug-eluting stents in off-label indications. To date no studies have detailed the in-vivo completeness of DES coverage at different time points. ...
Comparison of Neointimal Coverage by Optical Coherence Tomography of a Sirolimus-Eluting Stent Versus a Bare-Metal Stent Three Months After Implantation
ajconline.org (Jun 24 2008)
Cardiology
No detailed data regarding neointimal coverage of bare-metal stents (BMSs) at 3 months after implantation was reported to date. This investigation was designed to evaluate the neointimal coverage of BMSs compared with sirolimus-eluting stents (SESs) using optical coherence tomography. A prospective optical coherence tomographic follow-up examination was performed 3 months after stent implantation for patients who underwent BMS (n = 16) or SES implantation (n = 24). Neointimal hyperplasia (NIH) ...
Comparison of neointimal coverage by optical coherence tomography of a sirolimus-eluting stent versus a bare-metal stent three months after implantation.
NCBI HomePage (Jun 24 2008)
Cardiology
Comparison of neointimal coverage by optical coherence tomography of a sirolimus-eluting stent versus a bare-metal stent three months after implantation. Am J Cardiol. 2008 Jul 1;102(1):27-31 Authors: Xie Y, Takano M, Murakami D, Yamamoto M, Okamatsu K, Inami S, Seimiya K, Ohba T, Seino Y, Mizuno K No detailed data regarding neointimal coverage of bare-metal stents (BMSs) at 3 months after implantation was reported to date. This investigation was designed ...
Effect of statin therapy on coronary fibrous-cap thickness in patients with acute coronary syndrome: Assessment by optical coherence tomography study.
NCBI HomePage (Jun 24 2008)
Cardiology
Effect of statin therapy on coronary fibrous-cap thickness in patients with acute coronary syndrome: Assessment by optical coherence tomography study. Atherosclerosis. 2008 May 15; Authors: Takarada S, Imanishi T, Kubo T, Tanimoto T, Kitabata H, Nakamura N, Tanaka A, Mizukoshi M, Akasaka T BACKGROUND: The thickness of coronary fibrous caps is a major determinant of vulnerable plaques. Several clinical trials have suggested that statin therapy could stabilize vulnerable plaques. Recently, ...
In vivo real time monitoring of vasoconstriction and vasodilation by a combined diffuse reflectance spectroscopy and Doppler optical coherence tomography approach
www3.interscience.wiley.com (Jun 21 2008)
Cardiology
Background and Objectives A combined diffuse reflectance (DR) spectroscopy and doppler optical coherence tomography (DOCT) approach may offer a powerful means for assessment of tissue function, and potentially provide a way for earlier cancer detection through non-invasive local blood supply measurements. The goal of the study was to compare a DR-derived blood-content-related index to a measure of local blood supply flow as furnished by DOCT during manipulations with blood circulation ...
Quantification of cardiac fiber orientation using optical coherence tomography
SPIE Digital Library (Jun 20 2008)
Cardiology
Christine P. Fleming, Crystal M. Ripplinger, Bryan Webb et al. Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart ... [J. Biomed. Opt. 13, 030505 (2008)] published Fri Jun 20, 2008.
In vivo real time monitoring of vasoconstriction and vasodilation by a combined diffuse reflectance spectroscopy and Doppler optical coherence tomography approach.
NCBI HomePage (Jun 20 2008)
Cardiology
In vivo real time monitoring of vasoconstriction and vasodilation by a combined diffuse reflectance spectroscopy and Doppler optical coherence tomography approach. Lasers Surg Med. 2008 Jun 18;40(5):323-331 Authors: Douplik A, Morofke D, Chiu S, Bouchelev V, Mao L, Yang VX, Vitkin A BACKGROUND AND OBJECTIVES: A combined diffuse reflectance (DR) spectroscopy and doppler optical coherence tomography (DOCT) approach may offer a powerful means for assessment of tissue function, and potentially ...
In-vivo characterisation of coronary atherosclerosis with optical coherence tomography.
NCBI HomePage (Jun 19 2008)
Cardiology
In-vivo characterisation of coronary atherosclerosis with optical coherence tomography. Med J Aust. 2008 Jun 16;188(12):728 Authors: Barlis P, Ferrante G, Del Furia F, Di Mario C PMID: 18558898 [PubMed - in process]
Form to function: current and future roles for atherosclerosis imaging in drug development
Nature Publishing Group (Jun 18 2008)
Cardiology
There is a pressing need for robust imaging markers to assist in the development of drugs for the treatment of atherosclerosis. Conventional imaging methods provide quantitative and morphological data but may be inadequate for assessing a new generation of therapies that modify plaque biology directly. Here, we compare the main imaging modalities used to image atherosclerosis in the clinical-trial setting, and assess their ability to predict clinical outcomes for a ...
In-vivo characterisation of coronary atherosclerosis with optical coherence tomographymja.com.au (Jun 16 2008)
Cardiology
The burden of atherosclerosis has triggered intense interest in the study of “vulnerable” plaques at high risk of rupture. Optical coherence tomography (OCT) has recently contributed to the in-vivo visualisation of plaque, providing unique insights into the atherosclerotic process, previously only attainable through postmortem examination. This technique uses near infrared light and an optical imaging wire attached to a patient interface unit with a pullback speed of up to 3.0 ...
Assessment of arterial characteristics in human atherosclerosis by extracting optical properties from polarization-sensitive optical coherence tomography.
NCBI HomePage (Jun 12 2008)
Cardiology
Assessment of arterial characteristics in human atherosclerosis by extracting optical properties from polarization-sensitive optical coherence tomography. Opt Express. 2008 May 26;16(11):8117-25 Authors: Kuo WC, Hsiung MW, Shyu JJ, Chou NK, Yang PN In this research, we assessed arterial characteristics in human atherosclerosis by determining both scattering and birefringence properties of vessel tissue from polarization-sensitive optical coherence tomography (PS-OCT) images. We demonstrated that optical characteristics including scattering coefficient (?(s)), effective anisotropy ...
Optical CT shows ACS thrombus imaging potential
MedWire News (Jun 10 2008)
Cardiology
MedWire News: Chinese scientists have demonstrated the ability of optical coherence tomography (OCT) to visualize acute thrombosis in animal models of atherosclerosis. Writing in the journal Heart, the team from the 2nd Affiliated Hospital of HarBin Medical University says their technique could be used in clinical applications such as thrombus detection in patients with acute coronary syndromes (ACS). Bo Yv and co-workers induced atherosclerosis in rabbits by feeding them a ...
Optical Coherence Tomography for Drug Eluting Stent Safety (ODESSA)
Home - ClinicalTrials.gov (Jun 8 2008)
Cardiology
Increasing lesion complexity in percutaneous coronary interventions (PCI) has warranted the use of overlapping drug-eluting stents. Whether the substantial impairment of arterial healing observed at sites of overlap in preclinical pathologic studies persists in patients undergoing PCI is unknown. Consecutive patients with long lesions in native coronary vessels requiring stents in overlap are prospectively randomized to receive multiple sirolimus-,paclitaxel polymer-or zotarolimus eluting stents versus bare metal stents. The completeness of ...
Characterization of atherosclerosis plaques by measuring both backscattering and attenuation coefficients in optical coherence tomography
SPIE Digital Library (Jun 5 2008)
Cardiology
Chenyang Xu, Joseph M. Schmitt, Stephane G. Carlier et al. Intravascular optical coherence tomography (OCT) has been proven a powerful diagnostic tool for cardiovascular diseases. However, the optical mechanism for the qualitative observations are still absent. We address the fundamental issues that underlie the tissue characterization of OCT images obtaine ... [J. Biomed. Opt. 13, 034003 (2008)] published Thu Jun 5, 2008.
Fiber-optic rotational device, optical system and method for imaging a sample
A device, system and method for transmitting electro-magnetic radiation between at least two separate fibers (as well as for imaging a sample) are provided. For example, a first optical fiber and a second optical fiber may be provided, such that the first and/or second fibers is/are rotatable. At least one first optical arrangement may also be included which communicates with at least one end of the first optical fiber and/or ...
A device, system and method for transmitting electro-magnetic radiation between at least two separate fibers (as well as for imaging a sample) are provided. For example, a first optical fiber and a second optical fiber may be provided, such that the first and/or second fibers is/are rotatable. At least one first optical arrangement may also be included which communicates with at least one end of the first optical fiber and/or ...
Axsun Technologies Announces Exclusive Cardiac Supply Agreement for Advanced OCT Tunable Lasers with LightLab ImagingPR Newswire (Jun 2 2008)
Cardiology
BILLERICA, Mass., June 2 /PRNewswire/ -- Axsun Technologies Inc., a leading developer and manufacturer of advanced photonic components and subsystems, today announced that the company has entered into a multi-million dollar volume purchasing agreement with LightLab imaging. Under this multi- year exclusive agreement for cardiac Optical Coherence Tomography (OCT), Axsun will provide advanced tunable lasers for LightLab's next generation OCT imaging system.
Contribution of organized thrombus to in-stent restenosis after sirolimus-eluting stent implantation: optical coherence tomography findings
Oxford Journals (May 31 2008)
Cardiology
A 58-year-old man with hypercholesterolaemia and diabetes mellitus was admitted for exertional angina pectoris. Coronary angiography showed a 90% stenosis in the mid-right coronary