1. Estimation of Nonlinear Mechanical Properties of Vascular Tissues via Elastography

    Explore Article SpringerLink Home (Dec 3 2008) Cardiology

    ...u, Massachusetts Institute of Technology Department of Mechanical Engineering Cambridge MA 02139 USABrett E. Bouma, Massachusetts General Hospital, Harvard Medical School Wellman Center for Photomedicine Boston MA USA 02114Mohammad R. Kaazempur Mofrad, University of California Departm... (Read Full Article)

    Comment on Article Mentions:   Massachusetts Institute of Technology   Cambridge Technology   Harvard University

  2. Technology Gives 3-D View of Human Coronary Arteries

    Explore Article PhysOrg.com (Nov 17 2008) Cardiology

    ...ook at the interior of human coronary arteries, using an optical imaging technique developed at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH). In their report in the journal JACC: Cardiovascular Imaging, the research team describes ho......a rapid pace. We expect to see commercial devices available in a one- to two-year time frame," says Brett Bouma, PhD, of the Wellman Center, senior author of the report. "Our goal ... (Read Full Article)

    Comment on Article Mentions:   Harvard University   Massachusetts General Hospital   Brett E. Bouma

  3. Three-Dimensional Coronary Artery Microscopy by Intracoronary Optical Frequency Domain Imaging

    Explore Article imaging.onlinejacc.org (Nov 16 2008) Cardiology

    ...rien E. Desjardins, PhD*,,¶, Wang-Yul Oh, PhD*,, Lisa A. Bartlett, BS*,, Mireille Rosenberg, PhD*, Brett E. Bouma, PhD*,,¶ * Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts Department of Dermatology, Harvard Medical School, Boston, Massachusetts Dep... (Read Full Article)

    Comment on Article Mentions:   Harvard University   Milen Shishkov   Guillermo J. Tearney

  4. Distance From the Coronary Ostium as a Predictor of Vulnerable Plaque Morphology; An In-vivo Optical Coherence Tomography Study

    Explore Article Circulation (Nov 10 2008) Cardiology

    Background: Plaque morphology predicts its vulnerability to cause acute coronary events; most of which occur due to disruption of lipid-rich thin-cap fibroatheroma (TCFA). Observational studies show that lesions causing acute events are clustered in the proximal coronary artery segments. Aim: To evaluate whether the location of plaque in the coronary vessel is predictive of vulnerable plaque morphology identified by optical coherence tomography (OCT). Methods: OCT was performed in patients undergoing ... (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts General Hospital

  5. Imaging system and related techniques

    Explore Article PatFT » Page 1 of 1 (Nov 4 2008) Patents

    BACKGROUND OF THE INVENTION As is known in the art, fiber optic endoscopy is typically conducted by transmitting an image through an array of fibers often referred to as a fiber bundle. While successful for a variety of medical and non-medical applications, utilization of an array of fibers to form the image imposes constraints on the cost, diameter, and flexibility of the imaging device. In an attempt to overcome these ... (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts General Hospital

  6. Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging

    Explore Article Gastrointestinal Endoscopy (Sep 30 2008) Endoscopy , Microscopy

    ...y of the entire distal esophagus (∼6.0 cm) in patients.Design: A pilot feasibility study.Setting: Massachusetts General Hospital.Patients: Twelve patients undergoing routine EGD.Results: Comprehensive microscopy of the distal es......PhD, Patrick S. Yachimski, MD, Milen Shishkov, PhD, Gregory Y. Lauwers, MD, Mari Mino-Kenudson, MD, Brett E. Bouma, PhD, Norman S. Nishioka, MD, Guillermo J. Tearney, MD, PhD Corresponding Author Information Receiv... (Read Full Article)

    Comment on Article Mentions:   Brett E. Bouma   Guillermo J. Tearney   Milen Shishkov

  7. Doppler imaging using spectrally-encoded endoscopy

    Explore Article opticsinfobase.org (Sep 5 2008)

    Dvir Yelin, B. E. Bouma, J. J. Rosowsky, G. J. TearneyThe capability to image tissue motion such as blood flow through an e... (Read Full Article)

    Comment on Article Mentions:   Brett E. Bouma   Guillermo J. Tearney   Superlum

  8. Apparatus for controlling at least one of at least two sections of at least one fiber

    Explore Article PatFT » Page 1 of 1 (Aug 26 2008) Endoscopy , Microscopy , Patents

    An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first and second sections may be provided in a particular orientation that is perpendicular to an extension of the particular fiber. ... (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts General Hospital

  9. Comparison of coronary plaque characteristics between diabetic and non-diabetic subjects: An in vivo optical coherence tomography study

    Explore Article ScienceDirect (Aug 15 2008) Cardiology

    Aims Postmortem series have reported that subjects with diabetes mellitus have coronary plaques with larger necrotic cores and increased macrophage infiltration. Optical coherence tomography (OCT) is a high-resolution imaging modality that allows in vivo characterization of atherosclerotic plaques. Using OCT imaging, we compared in vivo plaque characteristics between diabetic and non-diabetic subjects. Methods Sixty-three patients undergoing cardiac catheterization were enrolled. OCT imaging was performed in culprit coronary arteries. Assessment of ... (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts General Hospital

  10. Apparatus And Method For Simultaneous Inspection At Different Depths Based On The Principle Of Frequency Domain Optical Coherence Tomography (Wo 2008/089406)

    Explore Article wipo.int (Jul 24 2008) Patents

    Exemplary embodiments of an apparatus are provided. For example, the exemplary apparatus can include at least one first arrangement providing at least one first electro- magnetic radiation to a sample, at least one second electro-magnetic radiation to a first reference and at least one third electro-magnetic radiation to a second reference. A frequency of radiation provided by the first arrangement generally varies over time. The exemplary apparatus may also include ... (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Harvard University

  11. In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography

    Explore Article Oxford Journals (Jul 14 2008) Cardiology

    ...ined as lipid-rich plaque (two or more quadrants) with fibrous cap thickness 1 Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRB 800, Boston, MA 02114, USA 2 Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA 3 Division of Cardiology, Nippon Medical School, Tokyo,... (Read Full Article)

    Comment on Article Mentions:   Massachusetts General Hospital   Guillermo J. Tearney   Brett E. Bouma

  12. Single-detector polarization-sensitive optical frequency domain imaging using high-speed intra A-line polarization modulation

    Explore Article opticsinfobase.org (Jun 10 2008)

    W. Y. Oh, B. J. Vakoc, S. H. Yun, G. J. Tearney, B. E. Bouma. We demonstrate a novel high-speed polarization-sensitive optical frequency domain imaging system e... (Read Full Article)

    Comment on Article Mentions:   Seok-Hyun Yun   Guillermo J. Tearney   Brett E. Bouma

  13. Fiber-optic rotational device, optical system and method for imaging a sample

    Explore Article PatFT » Page 1 of 1 (Jun 3 2008) Cardiology , Endoscopy , Patents

    A device, system and method for transmitting electro-magnetic radiation between at least two separate fibers (as well as for imaging a sample) are provided. For example, a first optical fiber and a second optical fiber may be provided, such that the first and/or second fibers is/are rotatable. At least one first optical arrangement may also be included which communicates with at least one end of the first optical fiber and/or ... (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts General Hospital

  14. Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography study.

    Explore Article Coronary Artery Disease (May 16 2008) Cardiology

    Coronary Artery Disease. 19(4):237-242, June 2008. Chia, Stanley a; Raffel, Owen Christopher a; Takano, Masamichi c; Tearney, Guillermo J. b; Bouma, Brett E. b; Jang, Ik-Kyung a Abstract: Objective: Statin therapy induces plaque regression and may stabilize atheromatous plaques. Optical coherence tomography (OCT) is a high-resolution in-vivo imaging modality that allows characterization of atherosclerotic plaques. We aimed to demonstrate the potential utility of OCT in evaluating coronary plaque (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Ik-Kyung Jang

  15. System and method for optical coherence imaging

    Explore Article PatFT » Page 1 of 1 (Apr 29 2008) Patents

    Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a ... (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts General Hospital

  16. System and method for optical coherence imaging

    Explore Article PatFT » Page 1 of 1 (Apr 29 2008) Patents

    A system and method for imaging of a sample, e.g., biological sample, are provided. In particular, at least one source electro-magnetic radiation forwarded to the sample and a reference may be generated. A plurality of detectors may be used, at least one of the detectors capable of detecting a signal associated with a combination of at least one first electro-magnetic radiation received from the sample and at least one second ... (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Johannes F. de Boer

  17. In Vivo 3D Comprehensive Microscopy of the Human Esophagus for the Management of Barrett's Patients

    Explore Article ScienceDirect (Apr 11 2008) Endoscopy

    No Abstract Provided (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts General Hospital

  18. Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands

    Explore Article PatFT » Page 1 of 1 (Apr 8 2008) Patents

    Apparatus, method, logic arrangement and storage medium are provided for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry ("LCI") signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source can be split into N spectral bands. The N spectral bands can be individually detected and processed to provide an increase in ... (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Johannes F. de Boer

  19. Evaluation of intracoronary stenting by intravascular optical coherence tomography

    Explore Article Heart (Apr 7 2008) Cardiology

    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA Background: Conventional contrast cinean... (Read Full Article)

    Comment on Article Mentions:   Massachusetts General Hospital   Guillermo J. Tearney   Brett E. Bouma

  20. Volumetric sub-surface imaging using spectrally encoded endoscopy

    Explore Article opticsinfobase.org (Jan 25 2008) Endoscopy , Microscopy

    D. Yelin, B. E. Bouma, G. J. Tearney Endoscopic imaging below tissue surfaces and through turbid media may provide improv... (Read Full Article)

    Comment on Article Mentions:   Brett E. Bouma   Guillermo J. Tearney   Harvard University

  21. High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing

    Explore Article opticsinfobase.org (Jan 15 2008)

    ...Y. Oh, S.H. Yun, B.J. Vakoc, M. Shishkov, A.E. Desjardins, B.H. Park, J.F. de Boer, G.J. Tearney, B.E. Bouma. Polarization sensitive optical coherence tomography (PS-OCT) provides a cross-sectional image of b... (Read Full Article)

    Comment on Article Mentions:   Seok-Hyun Yun   Guillermo J. Tearney   Brett E. Bouma

  22. Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography

    Explore Article opticsinfobase.org (Dec 20 2007) Cardiology , Endoscopy , Probes

    Ki Hean Kim, B. H. Park, Gopi N. Maguluri, Tom W. Lee, Fran J. Rogomentich, Mirela G. Bancu, Brett E. Bouma, Johannes F. de Boer, Jonathan J. Bernstein A two-axis scanning catheter was developed for 3D endos... (Read Full Article)

    Comment on Article Mentions:   Boris Hyle Park   Brett E. Bouma   Johannes F. de Boer

  23. Apparatus and method for low coherence ranging

    Explore Article PatFT » Page 1 of 1 (Dec 18 2007) Patents

    ...rly deflecting the line focus in the x-yplane (see FIG. 4D). See, (G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, Opt. Lett. 21, 543 (1996)) an... (Read Full Article)

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts General Hospital

  24. Optical coherence tomography (OCT) can successfully identify the characteristics of coronary plaques

    Explore Article google (Nov 4 2007) Cardiology

    ...stics of coronary plaques in patients with various cardiac symptoms. The report from researchers at Massachusetts General Hospital (MGH) will appear in the journal Circulation. “More than 1.2 million people die from coronary art......blood vessels. Study co-authors Guillermo Tearney, MD, PhD, of the MGH Pathology Department and the Wellman Center for Photomedicine at MGH, and Brett Bouma, PhD, also of the Wellman Center, developed the use of OCT to visualize ... (Read Full Article)

    Comment on Article Mentions:   Masamichi Takano   Massachusetts General Hospital   Ik-Kyung Jang

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