Articles from iovs.org

1. Thickness of Receptor and Post-receptor Retinal Layers in Patients with Retinitis Pigmentosa Measured with Frequency-Domain Optical Coherence Tomography (fdOCT)

   iovs.org (Nov 18 2008) Ophthalmology Explore Article

   PURPOSE: To better understand the effects of retinitis pigmentosa (RP) on post-receptor anatomy by measuring the thickness of the receptor, inner nuclear, retinal ganglion cell (RGC), and retinal nerve fiber layers (RNFL) with frequency-domain optical coherence tomography (fdOCT). METHODS: FdOCT scans were obtained from the horizontal midline in 30 patients with RP and 23 comparable age control subjects. Raw images were exported and the thickness of photoreceptor/RPE, inner nuclear, RGC ... (Read Full Article)
   

   Comment on Article

2. Follow-up of Mild Papilledema in Idiopathic Intracranial Hypertension with Optical Coherence Tomography

   iovs.org (Nov 18 2008) Ophthalmology Explore Article

   Purpose: To evaluate optical coherence tomography (OCT) measurement of peripapillary retinal nerve fiber layer (RNFL) thickness in patients with mild papilledema associated with idiopathic intracranial hypertension. Methods: Patients with papilledema underwent a complete ophthalmic examination, including peripapillary RNFL analysis using OCT (Fast RNFL thickness 3.4) at diagnosis and 3, 6, and 12 months after presentation. Age- and gender-matched control subjects underwent a similar evaluation. Changes in RNFL overall thickness and ... (Read Full Article)
   

   Comment on Article

3. Upper and lower tear menisci on contact lenses

   iovs.org (Nov 12 2008) Ophthalmology Explore Article

   Purpose: To measure upper and lower tear menisci on contact lenses using real time optical coherence tomography (OCT). Methods: Both eyes of 20 adapted contact lens wearers were imaged when they wore two types of silicone hydrogel lenses, balafilcon A on one eye and galyfilcon A on the other eye. The height, radius, and area of upper and lower tear menisci were obtained before, immediately after, and 20 minutes after ... (Read Full Article)
   

   Comment on Article Mentions:   University of Miami

4. Validation of Spectral Domain Optical Coherence Tomographic Doppler Shifts Using an In-Vitro Flow Model

   iovs.org (Nov 12 2008) Ophthalmology Explore Article

   Purpose: The validation of velocity measurements produced by spectral domain optical coherence tomography (SD-OCT) in an in vitro laminar flow model. Methods: A 30cc syringe filled with skim milk was inserted into a syringe pump. Intravenous (IV) tubing connected the syringe within the pump to a glass capillary tube (internal diameter = 0.579mm) shallowly embedded in agarose gel, then to a collection reservoir. SD-OCT imaging was performed with an anterior ... (Read Full Article)
   

   Comment on Article Mentions:   University of Pittsburgh   Joel S. Schuman   Superlum

5. Adaptive Optics Scanning Laser Ophthalmoscopy Images Demonstrate Abnormal Cone Structure in a Family with the Mitochondrial DNA T8993C Mutation

   iovs.org (Nov 11 2008) Ophthalmology Explore Article

   Purpose: To study the effect of mitochondrial DNA (mtDNA) mutation T8993C on cone structure in a family expressing neurogenic muscle weakness, ataxia, retinitis pigmentosa (NARP) syndrome. Methods: Five family members were studied, using clinical examination, nerve conduction studies, perimetry, optical coherence tomography (OCT) measures of central retinal thickness and electroretinography. High-resolution images of cone structure using adaptive optics scanning laser ophthalmoscopy (AOSLO) were obtained in 4 subjects with stable fixation. ... (Read Full Article)
   

   Comment on Article

6. Longitudinal Variability of Optic Disc and Retinal Nerve Fiber Layer Measurements

   iovs.org (Oct 28 2008) Ophthalmology Explore Article

   PURPOSE. To evaluate the longitudinal variability of optic disc and retinal nerve fiber layer (RNFL) measurements obtained from optical coherence tomography (OCT), scanning laser polarimetry (SLP), and confocal scanning laser ophthalmoscopy (CSLO). METHODS. Forty-five normal and 43 glaucomatous eyes of 88 subjects were analyzed in this longitudinal study. RNFL thickness was measured by OCT (StatusOCT; Carl Zeiss Meditec, Dublin, CA) and SLP (GDx VCC; Carl Zeiss Meditec). Neuroretinal rim area ... (Read Full Article)
   

   Comment on Article Mentions:   Chris K. S. Leung   Robert N. Weinreb   The Chinese University of Hong Kong

7. Comparison of Macular Thickness Measurements between Time Domain and Spectral Domain Optical Coherence Tomography

   iovs.org (Oct 28 2008) Ophthalmology Explore Article

   Macular thickness measurements obtained from spectral domain optical coherence tomography (OCT) were significantly greater than those obtained from time domain OCT because of the more posteriorly located retinal boundary (RPE in 3D OCT versus the inner and outer segment photoreceptor interface in Stratus OCT). Lower measurement variability was observed in spectral domain OCT. Clinicians should be aware of the measurement differences between the two instruments. (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Chris K. S. Leung   Robert N. Weinreb

8. Quantitative Optical Coherence Tomography Findings in Various Subtypes of Neovascular Age-Related Macular Degeneration

   iovs.org (Oct 28 2008) Ophthalmology Explore Article

   PURPOSE. To compare the volume of various spaces visible on optical coherence tomography (OCT) images in different angiographic lesion subtypes of neovascular age-related macular degeneration (AMD). METHODS. Sixty-six cases of previously untreated, active subfoveal choroidal neovascularization (CNV) associated with AMD were retrospectively collected. CNV lesions were classified as occult with no classic CNV, minimally classic CNV, predominantly classic CNV, or CNV lesions with associated retinal angiomatous proliferation (RAP). Corresponding OCT ... (Read Full Article)
   

   Comment on Article Mentions:   Alexander Walsh   Keck School of Medicine   Srinivas R. Sadda

9. Phase-Contrast OCT Imaging of Transverse Flows in the Mouse Retina and Choroid

   iovs.org (Oct 28 2008) Ophthalmology Explore Article

   PURPOSE. To test the hypothesis that a novel phase-contrast optical coherence tomography (OCT) system can image retinal and choroidal vessels in the living mouse. METHODS. A high-speed spectral domain optical coherence tomography (SDOCT) system, which measures the reflections for the entire depth of the retina at once with each axial scan (A-scan), was developed for mouse retinal imaging. Acquiring multiple A-scans over a transverse line across the mouse retina offers ... (Read Full Article)
   

   Comment on Article

10. Ultrahigh-Speed Optical Coherence Tomography for Three-Dimensional and En Face Imaging of the Retina and Optic Nerve Head

    iovs.org (Oct 28 2008) Ophthalmology Explore Article

    Ultrahigh-speed swept-source optical coherence tomography (OCT) imaging of the retina and optic nerve is demonstrated at 249,000 axial scans per second and 1060 nm, while methods for en face visualization of the retina, choroid, and lamina cribrosa are investigated. (Read Full Article)
    

    Comment on Article Mentions:   Desmond C. Adler   University of Pittsburgh   Massachusetts Institute of Technology

11. Simultaneous OCT/SLO/ICG Imaging

    iovs.org (Oct 28 2008) Ophthalmology Explore Article

    Purpose: To evaluate how information from combined coronal Optical Coherence Tomography (OCT) and confocal laser scanning ophthalmoscopy (SLO) with integrated simultaneous Indocyanine Green dye (ICG) angiography can be used in the diagnosis of a variety of macular pathologies. Methods: A compact chin-rest based OCT/confocal imaging system was used to produce the OCT image and excite fluorescence in ICG dye. The same eye fundus area can be visualized with coronal (C-scans, ... (Read Full Article)
    

    Comment on Article Mentions:   George M. Dobre   Adrian G. Podoleanu   University of Kent

12. Three Dimensional Optical Coherence Tomography (3D-OCT) Image Enhancement with Segmentation Free Contour Modeling C-Mode

    iovs.org (Oct 28 2008) Ophthalmology Explore Article

    Purpose: To develop a semi-automated method to visualize structures of interest (SoI) along their contour within three-dimensional, spectral domain optical coherence tomography (3D SD-OCT) data, without the need for segmentation. Methods: Using two SD-OCT devices (an ultrahigh resolution prototype of our own design and Cirrus OCT (Carl Zeiss Meditec, Dublin, CA)), we obtained 3D SD-OCT data within 6x6x1.4 mm and 6x6x2 mm volumes, respectively, centered on the fovea in healthy ... (Read Full Article)
    

    Comment on Article Mentions:   University of Pittsburgh   Massachusetts Institute of Technology   James G. Fujimoto

13. Retinal and Optic Disc Findings in Adolescence: A Population-Based OCT Study

    iovs.org (Oct 3 2008) Ophthalmology Explore Article

    PURPOSE. To examine the distribution of macular and peripapillary nerve fiber layer (NFL) thickness and optic disc parameters in early-adolescence Australian children and to compare these with previously reported findings in younger children. METHODS. The Sydney Childhood Eye Study is a population-based cross-sectional survey of children’s eye health. During 2004 and 2005, 2367 (75.3%) of 3144 eligible year 7 students from a random cluster sample of 21 secondary schools in ... (Read Full Article)
    

    Comment on Article Mentions:   Paul Mitchell   University of Sydney

14. Evaluation of Time Domain and Spectral Domain Optical Coherence Tomography in the Measurement of Diabetic Macular Edema

    iovs.org (Oct 1 2008) Ophthalmology Explore Article

    PURPOSE. To evaluate macular thickness and volume measurements and their intrasession repeatability in two optical coherence tomography (OCT) systems: the Stratus OCT, a time domain system, and the Cirrus HD-OCT, a spectral domain system (both by Carl Zeiss Meditec, Inc., Dublin, CA), in the context of diabetic macular edema (DME). METHODS. Thirty-three eyes of 33 diabetic patients with clinically significant macular edema (CSME) were scanned in a single session by ... (Read Full Article)
    

    Comment on Article Mentions:   Carl Zeiss Meditec   Zeiss Cirrus HD-OCT   Zeiss Stratus OCT

15. Comparison of lens thickness measurements using the Anterior Segment Optical Coherence Tomography and A-scan ultrasonography

    iovs.org (Sep 23 2008) Ophthalmology Explore Article

    Purpose: To assess lens thickness (LT) measurements with anterior segment optical coherence tomography (AS-OCT) in comparison with A-scan ultrasonography (A-scan US). Methods: 66 eyes of 48 phakic elderly volunteers aged 50+ years and 56 eyes of 56 young participants aged 18-40 years were enrolled in the study. LT was measured using the internal manual caliper tools in AS-OCT. The A-scan US measurements were based on the average of 10 consecutive ... (Read Full Article)
    

    Comment on Article

16. A Model for the Effect of Disturbances in the Optical Media on the OCT Image Quality

    iovs.org (Sep 23 2008) Ophthalmology Explore Article

    PURPOSE. The loss of quality of Optical Coherence Tomography (OCT) images resulting from disturbances in the optical media has been modeled. METHODS. OCT measurements were performed in two healthy volunteers using the StratusOCT. Optical disturbances were approached in three ways simulated with filters. The studied effects were: light attenuation (absorptive and reflective filters), refractive aberrations (defocusing lenses) and light scattering/straylight (scattering filters). The same examiner scanned the subjects with the ... (Read Full Article)
    

    Comment on Article Mentions:   Carl Zeiss Meditec   Zeiss Stratus OCT

17. Relationship of the optical coherence tomography signal to underlying retinal histology in the tree shrew (Tupaia belangeri)

    iovs.org (Aug 25 2008) Ophthalmology Explore Article

    PURPOSE. To interpret the retinal origin of the optical coherence tomography (OCT) signal by objectively (i.e. minimal investigator bias) aligning in vivo OCT longitudinal reflectivity profiles (LRPs) with corresponding vertical histological sections. METHODS. The Zeiss StratusOCT system was used to obtain retinal B-scans in vivo in eyes from adult tree shrews. Subsequently, the retinas were fixed and embedded. Semi-thin vertical sections through the retina were obtained from the same locations ... (Read Full Article)
    

    Comment on Article

18. Anterior Chamber Angle Measurement with Anterior Segment Optical Coherence Tomography: A Comparison between Slit Lamp OCT and Visante OCT

    iovs.org (Jul 25 2008) Ophthalmology Explore Article

    PURPOSE. To compare anterior chamber angle measurements obtained from two anterior segment optical coherence tomography (OCT) instruments and to evaluate their agreements and interobserver reproducibility. METHODS. Forty-nine eyes from 49 healthy normal subjects were studied. The anterior chamber angle was imaged with the Visante anterior segment OCT (Carl Zeiss Meditec, Dublin, CA) and the slit lamp OCT (SLOCT, Heidelberg Engineering, GmbH, Dossenheim, Germany) on one randomly selected eye in each ... (Read Full Article)
    

    Comment on Article Mentions:   Heidelberg Engineering   Carl Zeiss Meditec   Zeiss Visante OCT

19. Effect of Soft Contact Lenses on Optical Measurements of Axial Length and Keratometry for Biometry in Eyes with Corneal Irregularities

    iovs.org (Jul 24 2008) Ophthalmology Explore Article

    purpose. To assess the repeatability and reliability of IOLMaster (Carl Zeiss Meditec, Inc., Dublin, CA) axial length and keratometry measurements (K readings) with a soft contact lens on normal eyes. The method is designed for eyes with corneal irregularities or after endothelial keratoplasty. methods. Biometry was performed on 20 healthy right eyes of volunteer subjects with mean age, 27.3 ± 4.9 years; axial length, 24.77 ± 1.04 mm; and K ... (Read Full Article)
    

    Comment on Article Mentions:   Carl Zeiss Meditec

20. Retinal Nerve Fiber Layer Analysis in RP Patients Using Fourier-Domain OCT

    iovs.org (Jul 24 2008) Ophthalmology Explore Article

    purpose. To determine peripapillary retinal nerve fiber layer thickness (RNFL) abnormalities in patients with retinitis pigmentosa (RP) using Fourier-domain optical coherence tomography (Fd-OCT) and to evaluate the potential effect of cystoid macular edema (CME) or axial length on RNFL measurements in such patients. methods. Ninety-seven eyes of 52 patients with diagnoses of retinitis pigmentosa or Usher syndrome type II underwent complete ocular examination. Peripapillary RNFL thickness was measured using Fd-OCT ... (Read Full Article)
    

    Comment on Article

21. Differential Optical Densities of Intraretinal Spaces

    iovs.org (Jul 24 2008) Ophthalmology Explore Article

    purpose. To test the hypothesis that hyporeflective spaces in the neuroretina found on optical coherence tomography (OCT) examination have different optical reflectivities according to whether they are associated with exudation or degeneration. methods. Retrospective analysis of eyes with idiopathic perifoveal telangiectasia (IPT), diabetic macular edema (DME), idiopathic central serous chorioretinopathy (CSC), retinitis pigmentosa (RP), or cone dystrophy (CD) and eyes of healthy control subjects. OCT scans were performed. Raw scan ... (Read Full Article)
    

    Comment on Article

22. A New Method to Monitor Visual Field Defects Caused by Photoreceptor Degeneration by Quantitative Optical Coherence Tomography

    iovs.org (Jul 24 2008) Ophthalmology Explore Article

    purpose. To correlate the dimension of the visual field (VF) tested by Goldman kinetic perimetry with the extent of visibility of the highly reflective layer between inner and outer segments of photoreceptors (IOS) seen in optical coherence tomography (OCT) images in patients with retinitis pigmentosa (RP). methods. In a retrospectively designed cross-sectional study, 18 eyes of 18 patients with RP were examined with OCT and Goldmann perimetry using test target ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

23. Quantitative Subanalysis of Optical Coherence Tomography ...

    iovs.org (Jun 25 2008) Ophthalmology Explore Article

    PURPOSE. To investigate the effects of ranibizumab on retinal morphology in patients with neovascular age-related macular degeneration (AMD) using optical coherence tomography (OCT) quantitative subanalysis. METHODS. Data from 95 patients receiving intravitreal ranibizumab for neovascular AMD were collected. StratusOCT images were analyzed using custom software that allows precise positioning of prespecified boundaries on every B-scan. Changes in thickness/volume of the retina, subretinal fluid (SRF), subretinal tissue (SRT), and pigment epithelial ... (Read Full Article)
    

    Comment on Article Mentions:   Carl Zeiss Meditec   Zeiss Stratus OCT

24. Mapping Standard Automated Perimetry to the Peripapillary Retinal Nerve Fiber Layer in Glaucoma

    iovs.org (Jun 24 2008) Ophthalmology Explore Article

    purpose. To establish a map relating visual field (VF) test points to corresponding areas of the retinal nerve fiber layer (RNFL) measured with optical coherence tomography (OCT) in patients with glaucomatous optic neuropathy. methods. One hundred four consecutive subjects with open-angle glaucoma were prospectively selected. All subjects underwent standard automated perimetry (SAP) and imaging with OCT. Factor analyses of the mean thresholds for the SAP test points were performed, independently ... (Read Full Article)
    

    Comment on Article

1-24 of 55 // 1 2 3 »